CHAPTER 6 • NEUROHUMORAL CONTROL OF THE HEART AND CIRCULATION
This, along with aortic arch denervation,
Bilateral renal artery stenosis reduces the
which causes release of renin. This, in turn,
increases circulating angiotensin II, which
of the renin-angiotensin-aldosterone system
causes sodium and fluid retention by the
kidneys and an increase in blood volume,
which increases cardiac output. Increased
vasopressin (stimulated by angiotensin II)
contributes to the increase in blood volume.
Increased angiotensin II increases systemic
vascular resistance by binding to vascular
AT: receptors and by enhancement of sympa-
thetic activity. These changes in cardiac out-
put and system ic vascular resistance lead to a
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